Effect of diazepam on some blood parameters and some internal organs in healthy adult male rats

Abstract The present investigation was conducted to reveal the effect of administration of diazepam (2.5-5 mg/kg body weight orally) for 6weeks on some blood factors and weight of internal organs such as (heart, liver, lung, spleen and kidney) in adult male rats with age (2.5-3 months) and average weight (22216.79 gm). The results showed that diazepam at dose 2.5-5 mg/kg body weight caused a significant decrease in hemoglobin estimation, packed cell volume, numbers of white blood cell and the percentage of lymphocyte and there was also a significant increase in the percentage of neutrophil compaired with control. Further more, there was no significant difference in the percentage of eosinophil, basophil, monocyte and average weight of heart, liver, lung, spleen and kidney. It is concluded from present study that diazepam in two doses (2.5-5 mg/kg body weight) have adverse effect on some blood factors in healthy adult male rats.