Mirabegron-Induced Smooth Muscle Relaxation: Review of the Suggested Mechanisms

Section: Review Paper
Issue
Vol. 20 No. (2023): Volume 20 Issue
Published
Dec 1, 2023
Pages
195-200

Abstract

Background: Mirabegron operates through a distinct mechanism compared to antimuscarinic agents. Its activation of 3-adrenoceptors results in the relaxation of the bladder during the filling phase of micturition. The activation of 3-adrenoceptors, which are connected to Gs-proteins, is hypothesized to be the mechanism of mirabegron-induced smooth muscle relaxation. This coupling stimulates adenylyl cyclase, leading to an elevation of intracellular levels of cyclic adenosine monophosphate (cAMP). However, in rat and human corpus cavernosum, mirabegron induces relaxation through distinct mechanisms independently through the nitric oxide/cyclic guanosine monophosphate (NO-cGMP) pathway. Consequently, the precisemechanism by which mirabegron enhances relaxation is still not fully known. Aim: The main goal is to delve deeper into the complex mechanisms by which mirabegron causes smooth muscle relaxation in many tissues. Conclusion: Mirabegron and similar 3-adrenoceptor agonists hold promise for treating not only overactive bladder but also a range of other conditions including heart failure and metabolic disorders.

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Authors

Hani Almukhtar

Department of Pharmacology and Toxicology, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Rahma Saadaldain Almallah

Department of Clinical Pharmacy, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID

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Almukhtar, H., رحمة, & Saadaldain Almallah, R. (2023). Mirabegron-Induced Smooth Muscle Relaxation: Review of the Suggested Mechanisms. Iraqi Journal of Pharmacy, 20, 195–200. Retrieved from https://rjps.uomosul.edu.iq/index.php/iphr/article/view/21551