A Review of the Approved Data on Methods for Quantitative Determination of Sulfadiazine in Pharmaceutical Formulations

Section: Review Paper
Issue
Vol. 22 No. 1 (2025): Volume 22 Issue 1
Published
Mar 1, 2025
Pages
20-30

Abstract

Background: Recently, the consumption of pharmaceutical preparations and health products has increased to treat various diseases, such as urinary tract infections, treatment of some skin conditions, burns, Alzheimer's disease, streptococcal infection, bronchitis, and eye infections. Many of these preparations have the potential to harm patients or act as emergency pollutants in the environment. Sulfadiazine is one of the most commonly used antimicrobials for both human and animal infections. Aim: The purpose of this paper is to show how important it is to keep an eye on sulfadiazine using simple, accurate, precise, selective, and repeatable methods for estimation. Methods: For measuring pharmaceutical preparation amounts, spectrophotometry, chromatography, and electrochemical methods are best. Spectrophotometric techniques possess ease, accuracy with precision, and repeatability. Conclusion: Chromatographic techniques are selective, and they are more than their predecessors in that they possess speed and safety, but their drawback is that they are expensive. When compared to other methods, electrochemical techniques have very high sensitivity and selectivity. However, they are not very precise, and the sensors are affected by the current. Also, the supporting medium needs to be maintained all the time before it can be used.

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Authors

Ghaith Rabee Mohammed
ORCID
Ahmed A. J. Mahmood

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Safaa Polus Behnam

Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Gazi University, Ankara, Turkey

ORCID
Eman Mahmood Hassan
ORCID
Ridha Ridha M. Khudhuer Azzam
ORCID

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Rabee Mohammed, G., أوس, A. J. Mahmood, A., ايمان, Polus Behnam, S., Mahmood Hassan, E., & Ridha M. Khudhuer Azzam, R. (2025). A Review of the Approved Data on Methods for Quantitative Determination of Sulfadiazine in Pharmaceutical Formulations. Iraqi Journal of Pharmacy, 22(1), 20–30. Retrieved from https://rjps.uomosul.edu.iq/index.php/iphr/article/view/21558