Analysis of Some Regulatory Genes in Relation to Ferritin and Iron Metabolism among Thalassemia Patients in Mosul City

Section: Research Paper
Issue
Vol. 22 No. 1 (2025): Volume 22 Issue 1
Published
Mar 1, 2025
Pages
31-37

Abstract

Background: -thalassaemia is mostly caused by deletions in the alpha-globin gene complex, which result in either reduced or absent -globin chain synthesis. -globin chains are either absent or decreased in -thalassemia. Analyzing the regulatory genes (foxO1 and hepcidin) for iron and ferritin, in thalassemic patients was the goal of this study. Methods: Fifty individuals were selected for this study. Ten participants (5 females and 5 males) were healthy when they were recruited from general community and visited Al-Hadba'a Hospital (Mosul City) for blood withdrawal, while the forty patients (20 females and 20 males) have thalassaemia and ranged in age from 8 to 17. Results: Male participants had higher levels of iron and ferritin than female participants. Furthermore, there were notable differences in between male and female thalassaemic subjects. Additionally, ferritin and HbF were directly correlated with iron level and sex. Hepcidin expression analysis in healthy rather than thalassaemic participants found both down- and up-regulation; forkhead box O1 (foxO1) expression analysis demonstrated the reverse hemoglobin types pattern. Conclusion: In both thalassaemic and healthy subjects, gender was associated with the serum levels of iron, ferritin, and the genes that regulate them. Hepcidin and foxO1 synchronized with iron and ferritin in the human body.

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Authors

Mohammed KJ Alnori

Department of Clinical Laboratory Sciences, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Nuha S. Thanoon

Ninevah Health Director, Ninevah, Iraq

ORCID
Abeer Thanoon

Physiology, Biochemistry & Pharmacology, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

ORCID

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How to Cite

KJ Alnori, M., مدين, S. Thanoon, N., علي, Thanoon, A., & نهى. (2025). Analysis of Some Regulatory Genes in Relation to Ferritin and Iron Metabolism among Thalassemia Patients in Mosul City. Iraqi Journal of Pharmacy, 22(1), 31–37. Retrieved from https://rjps.uomosul.edu.iq/index.php/iphr/article/view/21559