The Effect of Chlorohexidine Gel Foam on the Salivary Tumor Necrosis Factor and Interleukine-6 after Extraction of lower Third Molar

Aim: This is study aimes to demonstrate the effect of chlorohexidine gelfoam on the salivary Tumor Necrosis factor and Interleukin-6 after extraction of lower third molar to compare these effect before and after extraction ' and to know the benefit of using chlorhexidine gelfoam after extraction of lower third molar . Material and method:-twenty four patients were involved, patients classified into group 1[control group],group 2 [chlorhexidine group] saliva was taken from all patients by using salivette before extraction and seven day after extraction then measure TNF andIL-6 by using [ELISA] kits' Results:- there is significance difference in (IL-6) after one week of extraction without treatment from the baseline (before extraction) and the result respectively was (1.960.51),( 6.205.22),and the result of (TNF-) appeared no significance difference before and after treated the result after treatment is(25.930.8) and before treatment is (95.2131.6) and the result of group used chlorhexidine gelfoam show significance difference in both (IL-6, TNF-) after and before treatment, the result of IL-6 after treatment is (16.9913.31) and before treatment is (1.570.18) and the result of (TNF-) after treatment is (5679.3) and before treatment is (102.9133.3) Conclusion:- the use of chlorohexidine gelfoam after extraction help to decrease the salivary TNF-. with significant difference and decrease level of IL-6 with a significant differences compare it with control group which enhance healing process and decrease the chance of infection.