Histological Study of Socket Healing after Tooth Extraction in Rabbits Treated with Short Term Diclofenac Sodium (Expermintal Study)

Aims: The aim of the present study is to investigate if short term therapy with diclofenac sodium of interferes with the time course of alveolar wound healing in rabbits. Materials and Methods: The sample included twelve rabbits; 6 rabbits received interamuscular injections of diclofenac sodium (10 mg/kg/day), one day before extraction, at a day of extraction and 4 days after extraction of the right mandibular incisors and 6 rabbits received interamuscular injections of normal saline. The animals were sacrificed in each group at 7, 14 and 21 days after tooth extraction. Results: The present results showed that the effect of diclofenac treatment caused no signifcant decrease in bone formation of socket healing. Conclusion: Histological study of short term therapy with diclofenac sodium after tooth extraction caused non-significant decrease in bone formation of extraction sockets healing in rabbits.