The effect of seed extract of Peganum harmala on growth of Leishmania torpica major promastigotes parasite in vitro.

Section: Article
Published
Jun 24, 2025
Pages
510-518

Abstract

Peganum harmala Leishmania major . 0,25-0,5 /3 96,72,48,24 0,25 /3 1,41 , 1,621, 2,126 0,5 /3 1,70 ,2,48 , 2,622 2 ,4 ,6 , , .The present study investigates the effect of seeds extract from Peganum harmala on the growth of Leishmania major parasite in vitro, and follows its effect in vivo through delayed hypersensitivity. The researcher used two concentrations of the seeds extraction 0.25, 0.5 mg/ml, and the amount of the parasite number has been calculated along 24, 48, 72, 96 hours in vitro, which shows a great decrease in parasite number with both concentrations of seeds extract in contrast with control. Also the results showed dependence on the delayed hypersensitivity, increase of left food pad swellings reach to 1.41 , 1.62 , 2.126 for mice treated after infected with 0.25 mg/ml ,and reach to 1.70 , 2.48 , 2.622 when treated with 0.5 mg/ml along 2,4,6 week while the infected not treated mice had no responses by delayed hypersensitivity for the same periods . So the results proofed the effectiveness of seeds extract from Peganum harmala on the reduction parasite number in vitro and in vivo.

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