Histopathological Changes in brain of the Experimental Balbc mice after induced toxoplasmosis

. 5-60 : 5 . . 10 13 . 15 . . 20 . () . . 30 . 60 .Induction of toxoplasmosis in the laboratory mice(balbc) after isolation of Toxoplasma gondii from aborted women placentae. Brains were removed , fixed, and sectioned into thin sections in period ranged between 5-60 days after infection, and main results were:After (5) days of infection parasitemia was observed and rhexis and haemorrhage of blood vessels and infiltration of monocytes and lymphocytes were seen near tachyzoids inside the blood vessel and penetration of the parasites into the brain tissues were observed with adhesion of these tachyzoids with the neurons and infiltration of glial cells were also observed. Rarely gliaosis and cell oedema and enlargement of endothelial cells of blood vessels occured . After (10) days of infection endodyogeny of parasites and focal gliosis were formed associated with the appearance of vaculation and focal necrosis in neurons with oedema near the membrane of leptomeninges. After (13) days of infection location of tissue cysts in necrotic loci were observed and the beginning of the formation of daughter cysts as a result of the constriction of mother tissue cysts .. After(15) days inflammatory cells infiltration represented by monocytes and lymphocytes around necrotic regions which represent lodging of tissue cysts. Furthermore, encephalitis was diagnosed through infiltration of inflammatory cells represented by monocytes and lymphocytes in the cortex in addition to presence of necrosis and oedema in the brain tissues. After (20) days continuity of tissue cysts formation and necrosis in neurons and accumulation of cysts in different sizes and appearance of gliosis and deposition of haemosiderine and continuity of neuron necrosis in the brain tissue. Clear infiltration of glial cells with monocytes and lymphocytes near granular layer in brain tissue. After (30) days distinct necrosis, oedema which are the two distinguishing characters in the brain tissue. After (60) days accumulation of different sizes of tissue cysts and distinction of diffuse gliaosis in addition to focal necrosis reaction represented by infiltration of cells near the cortex and its accumulation in gray matter region.