Thionyl Chloride: A Catalyst of Synthetic Chemical Interest

Section: Review Paper
Issue
Vol. 20 No. 2 (2023): Volume 20 Issue 2
Published
Dec 1, 2023
Pages
111-125

Abstract

Background: Particularly developed ingredients that are easily manufactured and utilized for additional exploitation are used in organic synthetic chemistry. Thionyl chloride serves as a significant illustration of such an ingredient. The usefulness of which has been discussed in a huge number of peer-reviewed papers. Aim: The literature that has been released since the previous assessment in 1980, which mainly focused on the responses of active methylene compounds, is where this review places its focus. In the present overview, we also discuss O- and N-nucleophiles. For the most part, patents have been disregarded in this analysis in order to keep it feasible. Conclusion: The authors concluded that SOCl2 has a variety of behaviors, including the ability to function as an initiator or a reactant, which makes it essential for the synthesis of many chemically reactive intermediates and final products. Additionally, SOCl2 can speed up and reduce the duration of traditionally long reactions, thereby raising its importance.

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Authors

Yasser Fakri Mustafa

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Noor Ahmed Waheed

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Noora Thamer Abdulaziz

Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Sawsan Hasan Hammodi

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID

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Fakri Mustafa, Y., Ahmed Waheed, N., Thamer Abdulaziz, N., & Hasan Hammodi, S. (2023). Thionyl Chloride: A Catalyst of Synthetic Chemical Interest. Iraqi Journal of Pharmacy, 20(2), 111–125. Retrieved from https://rjps.uomosul.edu.iq/index.php/iphr/article/view/21443