The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study

Section: Review Paper
Issue
Vol. 20 No. 2 (2023): Volume 20 Issue 2
Published
Dec 1, 2023
Pages
99-110

Abstract

Background: The problem of drug side effects necessitates the design, synthesis, and development of novel therapeutic agents that possess high activity with minimal side effects. According to the structure-activity relationship, the dioxolane moiety is found in many natural therapeutic agents and plays an important role in their medical action. Synthetic dioxolane conjugates have been studied in a variety of biological fields, including cytotoxicity, antibacterial, antifungal, antiviral, antioxidant, and anti-inflammatory activity, and have demonstrated a distinct potency that encourages further research in this mode. Aim: This review highlights the most recent studies on dioxolane ring conjugates in various biological fields as a promising bioactive heterocyclic scaffold. Conclusion: The hydrogen bonding of the oxygen atoms in this heterocyclic ring with the target site may be responsible for the enhanced ligand-target interactions and improved bioactivity.

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Authors

Yasser Fakri Mustafa

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Ahmed A. J. Mahmood

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Moath Kahtan Bashir

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID
Mahmood Khudhayer Oglah

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID

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Fakri Mustafa, Y., ياسر, A. J. Mahmood, A., معاذ, Kahtan Bashir, M., محمود, Khudhayer Oglah, M., & أحمد. (2023). The Influence of Dioxolane Ring Conjugates on Biological Activities: A Review Study. Iraqi Journal of Pharmacy, 20(2), 99–110. Retrieved from https://rjps.uomosul.edu.iq/index.php/iphr/article/view/21448