Relationship between Dietary Intake of Antioxidant (Vitamins C, E, and Selenium) with Semen Quality

Section: Original Articles
Issue
Vol. 3 No. 1 (2015): Volume 3 Issue 1
Published
Jan 15, 2015
Pages
1-5

Abstract

Background and aim: oxidative stress is detrimental to semen quality and has a significant role in the etiology of male subfertility. This study aimed at examine the relationship between dietary intake of antioxidant (vitamins c, e, and selenium) with semen quality. Materials and method: Dietary intake of antioxidants was compared between 35 men with oligolastheno/ teratazoospermic (cases) and 35 normospermic volunteers (controls) attending fertility clinic in al Batool Hospital in Mosul, Iraq. All participants were nonsmokers and matched according their age and Body Mass Index (BMI). Nutrient consumption was calculated using a semi- quantitative food frequency questionnaire. Semen samples were collected and were assessed by measuring volume, concentration, motility and morphology. Results: infertile subjects had a significantly lower intake of Selenium compare to control ones (p<0.001). Dietary intake of vitamin C and E was lower than recommended values in 59.4% of case group that was significantly different from control ones (p<0.05). In the control group, 36.4 and 40.9% of participants had an insufficient dietary intake of vitamin C and E, respectively. Significant correlations were found between Vitamin E (r=0.5, p<0.001), Vitamin C (r=0.6, p<0.001) and percentage of motility and also between vitamin E and morphology (r=0.3, p=0.03), Selenium and concentration (r=0.4, p=0.004) in all participants. Conclusion: In summary, a low intake of antioxidants, and vitamin E were related to poor sperm concentration and motility.

References

  1. Andersen, A. (2000). High frequency of sub-optimal semen quality in an unselected population of young men. Human Reproduction, 15(2), 366-372. http://dx.doi.org/10.1093/humrep/15.2.366
  2. Batra, N., Nehru, B., & Bansal, M. (2004). Reproductive potential of male Portan rats exposed to various levels of lead with regard to zinc status. BJN, 91(03), 387. http://dx.doi.org/10.1079/bjn20031066
  3. Carlsen, E., Giwercman, A., Keiding, N., and Skakkebaek, N. (1992). Evidence for decreasing quality of semen during past 50 years. BMJ, 305(6854), 609-613. http://dx.doi.org/10.1136/bmj.305.6854.609
  4. Connor, K., Vickers, M., Beltrand, J., Meaney, M., and Sloboda, D. (2012). Nature, nurture or nutrition? Impact of maternal nutrition on maternal care, offspring development and reproductive function. The Journal Of Physiology, 590(9), 2167-2180. http://dx.doi.org/10.1113/jphysiol.2011.223305
  5. Dohle, g., colpi, g., hargreave, t., papp, g., jungwirth, a., and weidner, w. (2005). Eau guidelines on male infertility. European urology, 48(5), 703-711. http://dx.doi.org/10.1016/j.eururo.2005.06.002
  6. Eskenazi, B. (2004). Antioxidant intake is associated with semen quality in healthy men. Human Reproduction, 20(4), 1006-1012. http://dx.doi.org/10.1093/humrep/deh725
  7. Eslamian, G., Amirjannati, N., Rashidkhani, B., Sadeghi, M., and Hekmatdoost, A. (2012). Intake of food groups and idiopathic asthenozoospermia: a case-control study. Human Reproduction, 27(11), 3328-3336. http://dx.doi.org/10.1093/humrep/des311
  8. Greco, E. (2005). Reduction of the Incidence of Sperm DNA Fragmentation by Oral Antioxidant Treatment. Journal Of Andrology, 26(3), 349-353. http://dx.doi.org/10.2164/jandrol.04146
  9. Hauser, R., Temple-Smith, D., de Kretser, D., and Southwick, J. (1995). Fertility in cases of hypergonadotropic azoospermia. Fertil Steril., Mar;63(3), 631-636.
  10. Hawkes, W., Kelley, D., & Taylor, P. (2001). The Effects of Dietary Selenium on the Immune System in Healthy Men. BTER,81(3),189-213. http://dx.doi.org/10.1385/bter:81:3:189
  11. Hosseini, B. and Eslamian, G. (2014). Association of Dietary Factors With Male and Female Infertility: Review of Current Evidence.Thrita,3(3). http://dx.doi.org/10.5812/thrita.20953
  12. Iwanier, K. and Zachara, A. (1995). Selenium supplementation enhances the element concentration in blood and seminal fluid but does not change the spermatozoal quality characteristics in subfertile men. Am Soc Androl., 16(5), 441-441.
  13. Jequier, A. (2000). Who manual for the standardized investigation and diagnosis of the infertile male. the obstetrician and gynaecologist, 2(4), 55-55. http://dx.doi.org/10.1576/toag.2000.2.4.5
  14. Lioret, s., McNaughton, A., Crawford, D., Spence, A., Hesketh, K., and Campbell, J. (2012). Parentsdietary patterns are significantlycorrelated: findings from the Melbourne Infant Feeding Activity and Nutrition Trial Program. Br J Nutr, 108(3), 518-526.
  15. Mendiola, J., Torres-Cantero, A., Moreno-Grau, J., Ten, J., Roca, M., Moreno-Grau, S., and Bernabeu, R. (2009). Food intake and its relationship with semen quality: a case-control study. Fertility And Sterility, 91(3),812-818. http://dx.doi.org/10.1016/j.fertnstert.2008.01.020
  16. Mendiola, J., Torres-Cantero, A., Vioque, J., Moreno-Grau, J., Ten, J., & Roca, M. et al. (2010). A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertility And Sterility,93(4),1128-1133. http://dx.doi.org/10.1016/j.fertnstert.2008.10.075
  17. Murata, M. and Kawanishi, S. (2000). Oxidative DNA Damage by Vitamin A and Its Derivative via Superoxide Generation. Journal Of Biological Chemistry, 275(3), 2003-2008. http://dx.doi.org/10.1074/jbc.75.3.2003
  18. Price, K., Bacon, J., and Rhodes, M. (1997). Effect of Storage and Domestic Processing on the Content and Composition of Flavonol Glucosides in Onion ( Allium cepa ). J. Agric. Food Chem., 45(3), 938-942. http://dx.doi.org/10.1021/jf9605916
  19. Rahman, M., Wahed, A., Fuchs, J., Baqui, H., and Alvarez, O. (2002). Synergistic effect of zinc and vitamin A on the biochemical indexes of vitamin A nutrition in children. Am J Clin Nutr. 2002, 75(1), 9298.
  20. Safarinejad, M., Hosseini, S., Dadkhah, F., and Asgari, M. (2010). Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: A comparison between fertile and infertile men. Clinical Nutrition,29(1),100-105. http://dx.doi.org/10.1016/j.clnu.2009.07.008
  21. van Helden, Y., Keijer, J., Heil, S., Pico, C., Palou, A., and Oliver, P. et al. (2009). Beta-carotene affects oxidative stress-related DNA damage in lung epithelial cells and in ferret lung. Carcinogenesis, 30(12), 2070-2076. http://dx.doi.org/10.193/carcin/bgp186
  22. WHO. (2000). WHO Manual for the Standardised Investigation and Diagnosis of the Infertile Couple. Cambridge: Cambridge University Press,.
  23. Wong, Y., Merkus, M., Thomas, M., Menkveld, R., Zielhuis, A., and Steegers-Theunissen, P. (2002). Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002 ;77(3):491-8., Mar (77)(3), 491-498.
  24. Young, S., Eskenazi, B., Marchetti, F., Block, G., & Wyrobek, A. (2008). The association of folate, zinc and antioxidant intake with sperm aneuploidy in healthy non-smoking men. Human Reproduction, 23(5), 1014-1022. Retrieved from: http://dx.doi.org/10.1093/humrep/den036

Authors

Khaeria Hussein Al Jebory

Specialist Nurse / Alhaweja General Hospital

Salwa Hazim Al Mukhtar

Assistant Professor/ College of Nursing/ University of Mosul

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