Factors Affecting Health Related Quality of Life in Adult with Beta – Thalassemia Major in Nineveh Province

Background: Thalassemia is a common genetic disorder on a global scale. Individuals with transfusion dependent beta-thalassemia experience a range of physical, psychological, and social disorders that ultimately result in a diminished quality of life.
Aim of study: To assess Health related quality of life in adult patients with transfusion dependent beta-thalassemia and to correlate it with various clinical parameters.
Methods: This study is designed as a case-control study involving 80 adult individuals transfusion dependent beta-thalassemia at Ibn Al-Atheer Hospital in Mosul city, along with 80 individuals who are considered healthy controls. To assess the Health-Related Quality of Life score, the researchers utilized the RAND Short Form 36 Questionnaire.
Results: In this study 32 men and 48 women were included. The mean age was 23.8 years 5.9. After reviewing the patients' quality of life, it was observed that the mean score for physical function was 79.715.7%, role of limitations due to physical health problem was 66.930.9%, role of limitation due to emotional problem was 73.343.3%, energy fatigue was 65.529.4%, social function was 77.2718.6%, pain was 72.218.6%, general health was 54.122.4%, emotional wellbeing was 58.226.8% and overall mean was 67.917.8% were significantly lower than healthy controls. The role of limitation due to emotional problem and emotional wellbeing were significantly lower in male compared to female patients with p-value of (0.004, 0.02) respectively.
Conclusion: In this study the Health Related Quality of Life in adults with transfusion dependent beta-thalassemia was reduced in all domains of short form 36 scores.