Measurement of Interleukine-6 and C-reactive Protein in Serum of Patients on Amlodipine Therapy

Aims: The aims of this udy were to compare between the immunological parameters (serum interleukin-6 (IL-6) and c-reactive protein (CRP) of patients suering from chronic cardiovascular diseases with amlodipine therapy and control group to determine the eects of the drug on those parameters. Materials and Methods: The udy was conducted on 42 subjects, 27 patients already on amlodipine therapy, aged ranged between 34-75 years. Fifteen healthy subjects of the same age group participated in this udy as a control group. The screening by medical hiory, examination (gingival enlargement scores) and blood samples to measure serum IL-6 and CRP was done once at base line visit. Results: The results obtained showed that amlodipine trherapy group had higher gingival overgrowth scores and immunological parameters than control group with signicant dierence at (p<0.05), also there was positive correlation but not signicant between CRP in serum and IL-6 (p< 0.05). Conclusion: The udy concluded that there is a signicant dierence in the GO score and immunological parameters in amlodipine therapy group as compared with healthy group.