Effect of β-tri-calcium phosphate in both its putty and granular forms in treating bone defects in sheep

The present study aims to evaluate and compare the effect of -tri-calcium phosphate granules and Putty on the healing of bony defects after induced injury on the tibia bone of sheep. Materials and Methods: Four healthy local breed male sheep all the sheep from the same farm. Four intervals were performed (2 weeks, 4 weeks, 6 weeks, 8 weeks). One tibia in each sheep was operated on at two two-week interval periods between each surgery (one surgery on each sheep making a total observation period of eight weeks). After two weeks of the last operation, the animals were euthanized based on a scheduled timeline. Results: The study reveals significant changes in osteoblasts, osteocytes, new capillaries, and histomorphometric measurements of bone marrow space over time, The study presents histological sections of sheep treated with granules and putty, revealing changes in bone marrow space histomorphometry and the presence of bone cells and capillaries. Conclusion: Although both kinds of -TCP putty and granules considerably improved bone fracture healing, the -TCP putty demonstrated a better and faster healing ability than the granules, with a marked improvement in the bone marrow area.