Synthesis, Characterization and Biological Studies of Selenium Dithiocarbamates and their Ni+2 and Cu+2 Complexes

Selenium metal react with (RNHC(S)S)2 where R= (Ph or o-tolyl) in refluxing toluene to give the compounds Se{RNHC(S)S}4. New complexes of the type [M2Se{RNHC(S)S}4Cl4], where M=Ni+2 or Cu+2, were prepared by reaction of Se{RNHC(S)S}4 with the metal chloride salts in 1:2 molar ratio.The compounds and complexes were characterized by atomic absorption, Infrared, U.V-Visible spectra, conductivity and magnetic measurements.Biological activity studies of the compounds and complexes as antimicrobial agents and the comparison of their activities with well known antibiotic (Ampicillinc, Gentamycine and Nystatine) using different straine of bacteria gram (+ve) and gram (-ve) in addition to fungi strain candida albicans.
The results indicated that complexes of the type [M2Se{S2CNHPh}4Cl4] are more active than [M2Se{S2CNHPhCH3-o}4 Cl4] while the selenium compounds Se(S2CNHPh)4 and Se(S2CNHPhC2H5)4 have moderate antimicrobial activity.