Study of Adenosine Deaminase Activity in Serum and Erythrocytes from Patients Affected by Acute and Chronic Leukemia

Adenosine deaminase specific activity was studied in serum and erythrocyte haemolysate for patients with leukemia.
The results show an increase with a significant difference of activity enzyme in serum and erythrocyte for patients compared with normal individuals of the same age and sex. The results obtained showed adenosine deaminase specific activity by unite of nmole of adenosine deaminated/min/mg protein in serum and erythrocyte haemolysate of patients were (35.425.64) and (94.485.99) respectively, while the mean value of activity in normal individuals were (13.681.72) and (60.566.55) in serum and erythrocyte haemolysate respectively.
The analysis also indicated that factors of sex, age and type of disease Acute Lymphocytic Leukemia or Chronic Myelocytic Leukemia have no effect on the activity of enzyme in patients serum and erythrocytic haemolysate. Moreover, higher concentration of total protein the decline in calcium level is found in the serum of the patients, while no significant deference of alkaline phosphates and hemoglobin in leukemia and normal individuals
Finally, the statistical results has been shown that positive correlation between activity enzyme and total protein (r=0.369;p<0.05) and negatively with calcium (r=0.505; p=0.0001) in patients serum.