Induction of Malformation of the External Eye with Adhesive Parts and Other External Malformations Caused by a Single Dose of Hypervitaminosis A in Swiss Mouse Embryo

The result of this study shows a new type of eye malformations, when the pregnant mice were injected intraperitoneally in the 7th day of gestation, with a single dose of 15,000 IU of VA. We suggest to call this malformation as the external eye with adhesive and hard components. The external eye appeared in all living embryos and the histological studies showed five different forms of it. A description of other external malformations were discussed in details.