Mutagenicity of some Antifungals in Aspergillus amstelodami

For different sublethal concentrations of the antifungals Griseofulvin, Fluconazole and Itraconazole were tested for their mutagenicity in conidia of the ascomycetous fungus Aspergillus amstelodami. Using three protocols : pretreatment, plate incorporation and growth mediation, Griseofulvin was effective only at its highest concentrations and in the plate incorporation and growth mediation methods. Fluconazole was inconsistent in its effect in the pretreatment and plate incorporation methods but consistently was positive at all it s concentrations in the growth mediation method. Itraconazole was consistently negative at all concentrations tested and in all three protocols used.