Activity of The Enzymes: Alkaline Phosphatase, 5-Nucleotidase and Acetylcholine Esterase in The Blood and Synovial Fluid for Some Rheumatoid Arthritis Patients

The research dealed with the study of the alkaline phosphatase, 5-nucleotidase and acetyl choline esterase activity in the blood and the synovial fluid of the Rheumatoid arthritis patients. The enzymes activities of the blood of Rheumatoid patients and healthy people have been compared, and of both sexes. Also, a comparison of these activities in the synovial fluid and the blood in 5 patients has been conducted.
The results in the blood showed an increase in the activity of alkaline phosphatase in male and female patients in different percentages. The activity of 5-nucleotidase remained with in its normal value in both sexes in all age groups, while the activity of acetylcholine esterase decreased in male and female patients in all age groups compared to healthy peoples.
The study of the synovial fluid showed a decrease in alkaline phosphatase and acetylcholine esterase enzymes activity while an increase in the 5-nucleotidase enzyme activity compared with that in blood for the same patients.
Therefore, the activity of the acetylcholine esterase. could be used as new marker for diagnosis rheumatoid artheritis in addition to the existing means.