Effects of Epigallocatechin-3-Gallate (EGCG) in Diabetes Mellitus as a DYRK1A inhibitor

Section: Review Paper
Issue
Vol. 20 No. 2 (2023): Volume 20 Issue 2
Published
Dec 1, 2023
Pages
168-173

Abstract

Background: Diabetes mellitus is a common metabolic disorder characterized by chronic high blood sugar levels due to impaired insulin secretion or action. Existing diabetic medications have limitations, including high costs and the risk of hypoglycemia. Aim: To overcome these challenges, researchers are exploring advanced treatments, and one potential path is studying plants and natural sources. Many plants include green tea (Camellia sinensis), rich in catechin derivatives, particularly epigallocatechin-3-gallate (EGCG), have shown promising effect because this agent may enhance beta cell proliferation, so it can produce dramatic response in management of diabetes mellitus and it is expected to reduce complication of this disease. Thorough data searching from September 2021 to June 2023 was used to conduct this study. The key terms diabetes mellitus, herbal treatment of diabetes, DYRK1A inhibitor, Epigallocatechin-3-gallate, and beta cell proliferation were concomitantly searched in Google Scholar, Web of Science, and PubMed in order to find relevant material. The publications that are presented here were published between 2014 and 2023. Conclusion: Collectively EGCG properties as a DYRK1A inhibitor may enhance cell proliferation that is promising effects in diabetes mellitus treatment.

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Authors

Doaa Khalid Ibrahim

Department of Pharmacology, College of Pharmacy, University of Mosul , Mosul, Iraq

ORCID
Nooralhuda Akram Yahya

Department of Pharmaceutics, College of Pharmacy, University of Mosul, Mosul, Iraq

ORCID

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Khalid Ibrahim, D., دعاء, Akram Yahya, N., & نورالهدى. (2023). Effects of Epigallocatechin-3-Gallate (EGCG) in Diabetes Mellitus as a DYRK1A inhibitor. Iraqi Journal of Pharmacy, 20(2), 168–173. Retrieved from https://rjps.uomosul.edu.iq/index.php/iphr/article/view/21449