Adenosine Deaminase Activity in Children Blood Affected by Major β - Thalassaemia in Nenava Governerate

Adenosine deaminase (EC : 3.5.4.4.) activity in serum of(20) cases of untreated - thalassaemia major, aged six month to one year of the both sexes, and (52) children of treated - thalassaemia major, aged 1.5 to11 years of the both sexes, and (50) normal children, aged six month to 12 years of both sexes also.
In the present investigation the activity adenosine deaminase in blood of untreated and treated cases of - thalassaemia major was compared with that in normal children. The results obtained showed adenosine deaminase specific activity in haemolysate of red cells and serum of untreated children was (164.145.6) and (35.10.9) n. mole of adenosine deaminase /min/mg protein respectively, while the mean value of activity in treated children was (86.42.53) and (25.060.46) in the haemolysate and serum respectively compared with (62.801.26) and (16.66 0.3) n. Mole. Statistical analysis showed a significant increase of activity in both cases.