Antibiotics Resistance of Moraxella catarrhalis from Proteins With Respiratory System Infections

Moraxella catarrhalis was isolated from sputum and swabs taken from patients with respiratory tract infections. 54 strains were used to determinate the susceptibility against (24) Antibiotics, and (17) strains for detecting minimum inhibitory concentration (MIC) values of (11) Antibiotics. Beta- Lactamase producing strains were (92.6%) which was correlated with resistance to penicillins and the first generation of cephalosporins. Results showed ahigh percentage of resistance for Cloxacillin, Penicillin G, Ampicillin and Amoxicllin and less to Cephalothin, cephalexin, and Ampiclox and intermediate resistance to Erythromycin, co-trimethoxazol and Tetracycline. High sensitivity against Tobramycin, Clarithromycin, Cefotaxim, Ceftrixon and Amoxi-clav. All strains showed absolute sensitivity (100%) to Neomycin, Norfloxacin, Ciprofloxacin, Azithromycin, Refampicin. Gentamycin, Chloramphenicol, Nitrofurantion and Nalidixic acid.
Results showed a high c values for Ampicillin and Amoxicillin which was (17.6%) and (5.8%) at a concentration (4) and (1) Mg/ml respectively. MIC values for Erythromycin was (5.8%) in (0.5) Mg/ml. low MIC for Azithromycin, Ceftrixon, Cefotaxim, Co-trimethoxazol, Ciprofloxacin Chloramphenicol and Amoxi-clav in (0.03-0.015) Mg/ml. best antibiotics for treatment are those mixed with substance that inhibit Beta lactamase such as Amoxiclav.