On the Possible Fusion and Haploidization of Nuclei Induced by Griseofulvin in Aspergillus amstelodami

The present work aimed to investigate two cytological aspects of the antifungal Griseofulvin (GRF) in the ascomycetous fungus Aspergillus amstelodami. The first was its ability to induce nuclear fusion and produce heterozygous diploids in the heterokaryotic mycelia, the second was its ability to induce haploidization of such diploids. To that end four sublethal or subinhibitory concentrations 500, 1000, 1250, 1500 g/ml were tested. Within the experimental conditions specified in the present work none of these two endpoints was fulfilled.