Effect of sodium nitroproxide inhibitor for yeast growth Candida albicans

ABSTRACT Nitric oxide (NO) has been recently recognized as a major mediator of resistance against fungus infection. Therefore, we investigated the effect of the pharmacological compound (Na nitroprusside) (SNP) as the NO donor on the in vitro growth of Candida albicans . The results of present study revealed that Na nitroprusside (NO donor) inhibited the C. albicans growth in a concentration - dependent manner, maximal inhibition concentration was observed in (SNP) with concentration (17.5mg/ml from growth media), there was complete inhibition of C. albicans growth occurs in comparison with the control without (SNP) .On other hand the addition (SNP) at concentration ranged from )10- 15mg/ml from growth media ( capable of restricting the growth of C. albicans . In contrast, no C. albicans growth inhibition occurs when (SNP) addition at concentration ranged from (0.625- 7.5mg/ml from growth media ) . The data suggest that the pharmacological compound (SNP) may be useful in the development of new therapeutic agents for treatment of Candida infections.