Synthesis and Antibacterial Evaluation of Some 1,2,3-Selenadiazole Derivatives

Abstract In this paper the synthesis of some 1,2,3-Selenadiazoles derivative is reported . Acetophenone (A) , Cyclohexanone (B) and menthone (C) each was treated with p-toluensulfoyl hydrazide in ethanol to give tosylhydrazones (1-3) , their cyclization with selenium dioxide gave 1,2,3-selenadiazoles (4-6) . Semicarbazone derivatives (7-9) were obtained by from (A-C) by their reaction with semicarbazide hydrochloride , treatment of semicarbazone (7-9) with selenium dioxide gave 1,2,3-Selenadiazoles (4-6). Compounds (A-C) were treatment with ethyl hydrazenoacetate to give the corresponding ethyl ester (10-12) .