Changes in blood parameters and kidney histology due to cadmium and selenium exposure of Female rat

The purpose of the study was to investigate the effect of Cadmiumand selenium on blood parameters and the subsequent effect in the tissueof female rat kidney . Female rats were divided into a control group andtow experimental groups treated with Cadmium, and Cadmium+Selenium. A control and tested animals were fed with the same standardchow , but Cadmium chloride, and Cadmium+ Selenium mixture wereorally gavaged daily for 28 days .At the end of the experimental period,blood samples were analyzed ,and packed cell volume ( PCV % ) ,hemoglobin ( Hb ) , number of total erythrocytes count and totalleucocytes count were determined . Blood analyses carried out in thepresent study showed that cadmium treatment causes different alterationsin blood parameters as indicated by significant decrease in erythrocytescount , hemoglobin value and packed cell volume percentage ascompared to control and Cd+selenium treated group . A number ofhistopathological change were observed in the kidney , includingglomerular shrinkage, karyolysis , degenerative cell and cell necrosis atcadmium treatment and pronounced recovery after selenium cosupplementedshowing a considerable antagonistic effects of Selenium +cadmium treatment . It can be concluded that the Cd exposure impair certainhematological mechanism and increase kidney tissue damage .Seleniumshowed beneficial effects to some extend. This study provide data ontoxic effect in female rats after dietary sub lethal supplementation toheavy metals.