Preparation, Characterization and Biological Activity of New Nickel(II) Complexes Containing Mixed Ligands

Nickel(II) complexes containing mixed ligands; semicarbazone (SCH){benzaldehyde semicarbazone (BSCH) or 2-fluorobenzaldehyde semicarbazone(FSCH)} and salicylaldehyde (SH) or anthranilic acid (AH) or 2-\ methylaminofuran (FH) have been prepared and characterized physicochemically.Complexes of the type [Ni(SCH)(LH)2](N03)2 {where SCH =BSCH or FSCH, LH = SH or AH or FH} have been proposed . Thebiological activities of the resulted complexes have been evaluated by agarplate diffution technique against five human pathogenic bacterial strains:Bacillus subtilis, Streptococcus pyogenes, Staphylococcus aureus,Pseudomonas aeruginosa and Proteus vulgaris. The complexes were foundto have antimicrobial activity on some gram-positive and gram-negativebacteria, in vitro. The effective concentrations ranging between 31.25-500J.lg/ml. Pseudomonas aeruginosa and Staphylococcus aureus were the mostsensitive bacteria followed by Proteus vulgaris.