Spermatogenesis in Mice exposed to Hydroxyurea: Protecitve effect of ntural apple cider vinegar

The effect of hydroxyurea at a close of 80mg/kg/day orally for (7) days on Spermatogenesis and the protective role of NACV (Natural apple cider vinegar) has been studied in mature male mice. Hydroxyurea caused a reduction in the number of spermatogonia and a significant decrease in primary spermatocytes and spermatids. Administration .of natural apple cider vinegar (20mg/kg/day) for (7) days after hydroxyurea caused a significant decrease in spermatogonia, spermatocytes and spermatids. The administration of natural apple cider vinegar with hydroxyurea produced a significant increase in the diameter of seminiferous tubules and spermatocyte count and an increase in spermatogonia count, while spermatid count did not return to normal. The present data indicate that hydroxyurea exerts inhibitory action on spermatogenesis, and natural apple cider vinegar has a protective effect against the damaging effect of hydroxyurea .