تأثیر خل التفاح الطبیعی على التغیرات الشکلیة للغدد اللعابیة فی الفئران المعالجة بالهیدروکسی یوریا

The effect of hydroxy urea (cytotoxic) d*g and cotreatment of natural apple cider vinegar on mice major salivary gland (parotid submandibular and sublingual) were studied. Hydroxy urea at a dose of 80 mg/kg/day produced a significant decrease in the diameter and height of parotid acini and sublingual gland acini compared to control also the diameter of intercalated duct and striated duct of parotid, submandibular, sublingual showed significant decrease compared to control. While the height of intercalated duct cells of parotid and submandibular gland declined but no to a significant level. Administration of natural apple cider vinegar (20 mg/kg) for (7) days after hydroxy urea treatment for (7) days caused a significant decrease in the diameter and height of parotid acini and sublingual and submandibular acini compared to control. While the diameter of parotid acini and sublingual acini decreased significantly as compared to hydroxy urea group. Also the diameter of striated duct of parotid and submandibular gland decreased significantly as compared to hydroxy urea group and control group. The height of intercalated duct cells of parotid and sublingual glands decreased significantly compared to control group. Administration of natural apple cider vinegar at the same time with hydroxy urea for (7) days showed a significant decrease in the diameter and height of parotid acini and sublingual acini compared to control also the diameter of intercalated duct and striated duct of parotid, submandibular and sublingual gland decreased significantly as compared to control. The height of striated duct cells of parotid, submandibular and sublingual decreased significantly compared to control. The result in this study showed that natural apple cider vinegar has no protective effect to the degenerative effect of hydroxy urea on salivary gland.