Preparation of a number of 4,3,1-oxadiazole substituted derived from imidazole and evaluation of their biological effectiveness

ABSTRACT Ethyl 2-(1H-imidazol-1-yl)acetate (A1) was synthesized by the reaction of ethylchloroacetate with imidazol, Then refluxed with hydrazine hydrate to obtain 2-(1H-imidazol-1-yl)acidhydrazid (A2) . (A2) was reaction with various substituted benzyldehyd to gain 6 novel compounds shiffe bases(A3-8).and 5-(1H-imidazol-1-yl)methyl)3-N-acetyl-2-(aryl)-1,3,4-(2H)-Oxadiazol (A9-12) were synthesized by the reaction of shiffe bases(A3-8)with acetic anhydride . In order to show the antibacterial activity of prepared compounds are evaluated against four types of common bacteria (psedomonus, Staphylococcus aureus, Eschershia coli, Klebsiella peneuomina). The result of biological study are compared with standered antibiotic (metheprem & Gentamycin) . The structure of the synthesized compounds are confirmed by I.R, 1H-NMR & 13C-NMR spectra and Some chemical physical data.