Spectrophotometric Determination of Oxymetazoline Hydrochloride in Pure and Pharmaceutical Preparations Using Diazo-coupling Reaction

A ccurate and simple spectrophotometric method has been suggested for the determination ofoxymetazoline hydrochloride (OMCl) in aqueous solution is developed. The present process included coupling of OMCl with diazotized sulphanilic acid reagent in the presence of sodium hydroxide. The orange colored azo dye formed very stable and soluble in water gives maximum absorption at 496 nm. The lineratey is obeyed over the range 20 400 mg / 25 ml (0.8 16g.ml-1) the molar absorptivity is equate to 2.30 104 l.mol-1cm-1. The proposed method has been used to the determination of OMCl in two formulations with satisfactories results.