Immunoligical study among pregnant and non-pregnant women with symptomatic and asymptomatic Urinary tract infection in Kirkuk city-Iraq

Abstract In this study an attempt was carried out to: estimate the: 1- prevalence of asymptomatic bacteriuria in pregnancy, its causative agents and their sensitivity pattern in Kirkuk city.2- Role of humoral immune response in women with symptomatic and a symptomatic urinary tract infection through the measuring of IgG,IgA, IgM,C3 and C4 levels in urine and serum of patients and comparing them with corresponding levels of healthy control groups. The results showed that the prevalence of asymptomatic (UTI) in pregnancy was (10%). E.coli was the commonest causative bacteria in both pregnant and non- pregnant with symptomatic and a symptomatic (UTI).The antibiotic ciprofloxacin, ceftriaxone and gentamicin was the most effective Regarding the immunological study: pregnant and non-pregnant subjects with symptomatic (UTI) showed significant increase in the level of IgG and IgA and no significant differences was noticed in the level of IgM as compared with control group. Significant differences between pregnant and non-pregnant subjects with symptomatic (UTI) was observed only in the level of IgM. Pregnant subjects with symptomatic (UTI) showed a significant decrease in the level of C4 as compared to control group, any significant differences were not observed between pregnant and non-pregnant in the level of C3 and C4. Compared to symptomatic (UTI) in pregnant subject asymptomatic (UTI) subjects recorded the highest serum levels of IgG,IgM, C3andC4, while the highest values of IgA was found in symptomatic UTI. Conclusion:- Bacteriuria or pregnancy changes different aspects of humoral immunity, thus the co-existence of pregnancy and bacteriuria may influence each other.