The effect of involuntary smoking on embryonic composition and tissue composition of the eye And the appearance of facial abnormalities in the embryo of the Swiss white mouse Mus musculus

ABSTRACT The present study aimed to investigate the effects of passive smoking to induce embryonic malformations and eye lesions during development of the swiss albino mice Mus musculus. The pregnant females were exposed to cigrate smoking at variable time periods (1.5,2,2.5,3) hour daily, which started at the 7th day of pregnancy until delivery of neonate. The results revealed no pregnant period prolongation in contrast to control group. The results showed at the exposure of the mice for (1.5)hrs daily for two weeks of passive smoking there were no morphological malformatios, but some histological features appeared such as scleral pyknotic, lens swelling. At (2)hrs of exposure daily, there were (15%) of the seen embryos showed malformations; one of these morphological defect was congested. But the histopathological features were central retinal hyperplasia, and corneal pyknosis. At(2.5)hrs exposure to passive smoking, (17%) of embryos showed limb deformity and some histopathological malformations such as lens dentation and apoptosis of some neural retinal cells. At(3)hrs exposure daily, (25%) of embryos suffered from morphological and histological malformations represented in face deformity, necrosis of inner plexiform layer and ganglion cells pyknosis of the retina, compared with the control group. * . () Passive moking Mus musculus (32.521.5) . (1.5) (2) (15%) . (2.5) (17%) . (3) (25%) .