Modification of pesticide toxicants Actara, Desis and Fabcosidine for larvae of Khabra Trogoderma granarium beetle with Prenobyl Piotoxide and phenobarbital

This study was designed to evaluate the toxicities of Actara, Decisand Vapcocidin and the effects of the mixed-function oxidase (mfo)enzymes inhibitor, piperonyl butoxide (pb ), and inducer, Phenobarbital(phb ), on the toxicities to the 15\ 2nd, 3rd, 4th and 51h instar larvae ofTrogoderma granarium, using the impregnated filter paper technique.Based on the 24h LC50 values, the three insecticides were highly toxic tothe larvae. Decis was about twice as toxic as Actara and both were greatlymuch more toxic than Vapcocidin. The toxicities of the three insecticides,generally, decreased as the Larval stage advanced (LC50 values in the 5-Larval instars were 1.7, 1.8, 2.2, 2.6, 3.1 0 l/filter paper, respectively, forDecis, 3.0, 3.5, 4.5, 6.0, 7.0 0 1/filter paper, respectively, for Actara and6.0, 8.0, 11.0, 13.0, 15.0 0 1/filter paper, respectively, for Vapcocidin) andit is considered most likely that the decrease is due to the increase in themfo enzymes activity. The mfo enzymes modifiers data showed that pband pbb greatly increased and decreased, respectively, the toxicities of thethree insecticides. The date also revealed that mfo insecticide detoxifingenzymes activity increased as the Larval stage advanced. The studysuggests that Actara would be an effective alternative to pyrethroidsagainst this insect.