Immune effects of partially purified polyamine oxidase from cerebrospinal fluid against infection with secondary hydatid disease in mice.III.Growth and development of hydatid cysts .

Section: Article
Published
Sep 1, 2007
Pages
115-124

Abstract

The study included immune response to infection with secondaryhydatid disease in BALB/c mice activated by partially purifiedCerebrospinal fluid-polyamine oxidase CSF-P AO with spermine (Spm)and infected with protoscoleces of Echinococcus granulosus. Thepathological changes occurred in mice activated by differentconcentrations of PA0(200-1600Jlg/10gm body weight) with constantconcentration (200 jlgl 1 Ogm body weight) of substrate (spermine), and bythe same concentration of spermine alone, were followed in comparisonwith positive control group along one month, depending on many criteria.These criteria included changes in numbers, weights and diameters ofhydatid cysts, and their percentage eduction. In addition, changes inweights of liver and spleen and their organ indices .The results revealedan obvious decrease in numbers, weights and diameters of secondaryhydatid cysts grown for one month in activated mice, in comparison withthe +ve control group, supported by elevation in the percentage ofreduction of hydatid cysts in activated mice.A decrease in the mean ofliver and spleen weights, and a variation in organ indices in activatedmice occurred within one month, whereas no change was observed in themean of spleen weight, in comparison with +ve control group.Therefore, it may be concluded here that P AO isolated from CSF withSpm could be considered as an effective immunumodulator againstinfection with secondary hydatid disease.

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How to Cite

[1]
A. Ali, اسماء, K. Flayeh, خولة, W. Ali, and وثبة, “Growth and development of hydatid cysts ”., EDUSJ, vol. 20, no. 1, pp. 115–124, Sep. 2007.